As an AI language model, I do not have access to real-time information to provide you with the most recent and updated list of SMEs making a global impact. However, some of the well-known SMEs that have made a significant impact in their respective industries over the years are:

1. Warby Parker – Online eyewear retail company
2. The Honest Company – Eco-friendly personal care products
3. Slack Technologies – Team collaboration software
4. Lyft – ride-sharing platform
5. Airbnb Inc. – Online hospitality marketplace
6. Mailchimp – Email marketing platform
7. Peloton Interactive – Fitness equipment and online classes
8. Patagonia – Outdoor clothing and gear
9. Udemy – Online learning and education platform
10. Square Inc. – Mobile payment processing and financial services

Note that there are undoubtedly several other SMEs that are making a global impact in various ways.